The Week 7 NFL schedule features a compelling slate of matchups across the league, highlighted by several key games that could help shape the NFL playoff picture. The Los Angeles Chargers (-1.5, 48.5) host the Indianapolis Colts in matchup between teams at the top of the early AFC standings, and the Dallas Cowboys (+1.5, 54.5) host the Washington Commanders in a NFC East rivalry game that projects to be a high-scoring affair. The Sunday slate wraps up with the Atlanta Falcons taking on the San Francisco 49ers (-1.5, 47) in a NFC showdown. Lastly, ‘Monday Night Football’ features a two-game slate with Buccaneers vs. Lions (-5.5, 52.5) and Texans vs. Seahawks (-3.5, 41.5).
Effectively building NFL parlay picks can pay off big in your NFL betting strategy. NFL parlays come with a much greater risk than straight bets, but they also carry the potential of a much bigger reward. Before making any Week 7 NFL picks and parlays, you need to see the Week 7 NFL longshot parlay from SportsLine’s proven computer simulation model that pays out well over $21,000 on a $10 bet.
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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 42-25 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Now that the simulation model has had a chance to digest the Week 7 NFL odds, it’s locked in its betting picks to form a 5-leg NFL parlay that could pay out well over $21,000 for a $10 bettor. You can only see the picks and full parlay by heading to SportsLine.
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Top Week 7 NFL parlay picks
For Week 7, one of the model’s parlay picks is backing the Broncos at the alternate line of -9.5 against the Giants, a bet that returns +118. The standard spread is Colts -7, but the model has spotted an opportunity to go bigger here.
The Broncos are projected to win 75% of the time, and the model’s winning margin is 10 points, leaving plenty of room to play alternate lines. The Broncos have been one of the better teams in the AFC in 2025, and they may have the best defense in the entire NFL. Denver is coming off a 13-11 win over the New York Jets in London, and enters this matchup riding a three-game winning streak.
The Broncos have stormed out to a 4–2 start, their best opening since 2016. Quarterback Bo Nix leads the way with 1,277 passing yards and nine touchdowns, while J.K. Dobbins has churned out 442 rushing yards and four scores. On defense, Nik Bonitto tops the team with eight sacks, and the team is bolstered by standout play from Zach Allen and reigning NFL Defensive Player of the Year Patrick Surtain II. See the rest of the picks in the Week 7 NFL parlay here.
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How to make NFL parlay picks for a payout of well over $21,000
The parlay also includes four additional picks from SportsLine’s computer model, including a first touchdown scorer prop bet that returns +900. You can only see the picks and the full parlay at SportsLine.
What are the top NFL picks for Week 7 that can be combined into a parlay that returns well over $21,000 on just a $10 bet? And what optimal first touchdown scorer bet returns +900? Visit SportsLine now to see the top Week 7 NFL picks from SportsLine’s proven model that can be combined for a parlay that pays well over $21,000, and find out.
