Two of the top teams in the American Conference clash when the 24th-ranked South Florida Bulls meet the North Texas Mean Green on Friday night. USF is coming off a 54-26 win over Charlotte on Oct. 3, while North Texas downed South Alabama 36-22 on Sept. 27. The Bulls (4-1, 1-0 American), who have won two in a row, are 1-1 on the road this season. The Mean Green (5-0, 1-0 American), who have outscored their opponents 224-100, are 3-0 on their home field in 2025.
Kickoff from DATCU Stadium in Denton, Texas, is at 7:30 p.m. ET. South Florida leads the all-time series 2-0. The Mean Green are 2.5-point favorites in the latest South Florida vs. North Texas odds, while the over/under for total points scored is 67.5 via SportsLine consensus. Before making any North Texas vs. South Florida picks, check out the college football predictions from the SportsLine Projection Model.
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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, the model has set its sights on South Florida vs. North Texas. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for North Texas vs. South Florida:
South Florida vs. North Texas spread
North Texas -2.5 at DraftKings Sportsbook
South Florida vs. North Texas over/under
67.5 points
South Florida vs. North Texas money line
North Texas -131, USF +110
South Florida vs. North Texas picks
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Why South Florida can cover
Senior quarterback Byrum Brown powers the Bulls’ offense. In five starts, he has completed 92 of 150 passes (61.3%) for 1,194 yards and 10 touchdowns with four interceptions. He has also carried 64 times for 282 yards (4.4 average) and three touchdowns. In last Friday’s win over Charlotte, he completed 19 of 34 passes (55.9%) for 211 yards and four touchdowns with two interceptions.
His top target is senior wide receiver Chas Nimrod, who is in his first year with the program. He spent the last two seasons at Tennessee. In five games, he has 19 receptions for 421 yards (22.2 average) and three touchdowns. In a 63-14 win over South Carolina State, he had four receptions for 119 yards (29.8 average) and two touchdowns. See which team to back at SportsLine.
Why North Texas can cover
Helping lead the Mean Green is redshirt freshman quarterback Drew Mestemaker. In five games, he has completed 106 of 156 passes (67.9%) for 1,247 yards and 11 touchdowns with zero interceptions. In a 51-0 season-opening win over Lamar, he completed 24 of 32 passes (75%) for 329 yards and three touchdowns. In a 45-38 overtime win over Army on Sept. 20, he completed 26 of 36 passes (72.2%) for 249 yards and one touchdown.
North Texas has a one-two punch at running back with sophomore Makenzie McGill II and freshman Caleb Hawkins. McGill leads the Mean Green in rushing, carrying 63 times for 318 yards (5.0 average) and four touchdowns. McGill has surpassed 100 yards rushing in two games. Hawkins, meanwhile, has carried 42 times for 307 yards (7.3 average) and seven touchdowns. He carried 16 times for 140 yards (8.8 average) and two touchdowns in the win over South Alabama. See which team to back at SportsLine.
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How to make South Florida vs. North Texas picks
SportsLine’s model is going Over on the total, projecting 73 combined points. It also says one side of the spread hits in well over 60% of simulations. You can only get the pick at SportsLine.
So who wins North Texas vs. South Florida, and which side of the spread hits well over 60% of the time? Visit SportsLine now to see which side of the South Florida vs. North Texas spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.
