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    You are at:Home»Sports»2025 college football picks, Week 5 odds, spreads, predictions via proven expert: This parlay returns +600
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    2025 college football picks, Week 5 odds, spreads, predictions via proven expert: This parlay returns +600

    onlyplanz_80y6mtBy onlyplanz_80y6mtSeptember 27, 2025003 Mins Read
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    2025 college football picks, Week 5 odds, spreads, predictions via proven expert: This parlay returns +600
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    The Week 5 college football schedule is one of the best of the years as it features a trio of elite matchups that all will impact the College Football Playoff field. The latest Week 5 college football odds list No. 4 LSU as a 1.5-point road underdog at No. 13 Ole Miss. No. 3 Penn State is -3.5 against No. 6 Oregon, while No. 5 Georgia is -2.5 against No. 17 Alabama. Other Week 5 college football lines of note include Tennessee (-7.5) vs. Mississippi State, USC (-6.5) vs. Illinois, South Carolina (-5.5) vs. Kentucky and Texas A&M (-6.5) vs. Auburn.

    Those games will draw most of the betting attention, but where are the best values for college football betting in Week 5? Before locking in any Week 5 college football picks on those game or others, be sure to see the top Week 5 college football expert picks, predictions and best bets from Thomas Casale.

    A frequent guest on national radio and TV shows to discuss college sports, Casale has been sports betting — and winning — for more than 30 years. After going 9-5 so far this season, including a 3-0 sweep in Week 4, he’s on a 22-11 roll in his SportsLine best bets column that dates back to last season. Anybody who followed him could have been way up.

    Now, he has turned his attention to the Week 5 college football odds and is sharing his top betting picks. If you parlay these college football betting picks, you could be looking at a return of around +600. Get his top college football picks at SportsLine.

    New users can also target the DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

    Top Week 5 college football expert predictions

    One of Casale’s top Week 5 college football picks: He’s backing No. 3 Penn State (-3.5) to cover at home against No. 6 Oregon in a Big Ten matchup with massive conference and College Football Playoff implications. 

    “This is a good spot to back Penn State,” Casale told SportsLine. “As good as Oregon has looked, they still haven’t beaten a team with a heartbeat. Penn State hasn’t either but there is one big difference, the Nittany Lions are the more experienced team with a lot of players that have been in the program for a couple of years.” See what other picks Casale likes at SportsLine. 

    How to make Week 5 college football picks 

    Casale has found two other college football picks he loves, including backing an underdog in a game where he says the wrong team is favored. You can only see his picks at SportsLine, and you can use promo code CHAMPIONSHIP to get your first month at SportsLine for just $1.

    What are the best bets for Week 5 of college football, and which underdog does Casale believe will win outright? Visit SportsLine now to see Thomas Casale’s college football best bets, all from a proven college football handicapper who is on an -11 roll on CFB best bets, and find out. 

    College expert Football odds parlay picks Predictions proven returns spreads week
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