The 2026 NFL playoffs are set, and teams like the Texans and Jaguars enter in on win streaks of nine and eight games, respectively, and could be highly sought after with NFL picks. Meanwhile, Green Bay is riding a four-game losing streak and is a 2.5-point favorite against the Bears on Saturday night, per the latest Wild Card Weekend NFL odds. Those two split their regular season matchups as they’ll tangle in the postseason for just the third time ever. The NFL line for that game matches Bills vs. Jaguars (-1.5) as the slimmest of the Wild Card Weekend NFL spreads, while the largest has the Rams favored by 10 points over the Panthers as Los Angeles is getting receiver Davante Adams (hamstring) back for the first time in nearly a month.
Other spreads include 49ers vs. Eagles (-6), Chargers vs. Patriots (-3.5) and Steelers vs. Texans (-3). The Jaguars opened as underdogs, but have flipped to slight favorites, joining the Eagles and Patriots as the home favorites of the opening round of the 2026 NFL playoffs. All of the updated Wild Card Weekend NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Wild Card Weekend NFL picks now.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2026 NFL playoffs on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, it has turned its attention to the latest Wild Card Weekend NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick.
Top Wild Card Weekend NFL predictions
One of the model’s strongest Wild Card Weekend NFL picks is the Steelers (+3, 38.5) covering at Houston on Monday night at 8 p.m. ET. These teams have the same 9-8 spread record, but Pittsburgh is 4-1 ATS over its last five, while Houston has failed to cover in two of its last three. While Houston has an elite defense, it allowed its most points (30) all year in Week 18 to a Colts team with a fourth-string rookie quarterback, which is no comparison to an Aaron Rodgers-led unit getting back a rested DK Metcalf. As for C.J. Stroud, he is 0-2 on the road in his playoffs career, failing to account for a touchdown in either loss. The Steelers are forecasted to cover over 50% of the time, with the Over hitting in well over 50% of simulations. See which other teams to pick here, and bet the Steelers using the DraftKings promo code, which offers $300 in bonus bets if your bet wins right here:
How to make Wild Card NFL picks
The model has also made the call on who wins and covers in every other game on the Wild Card Weekend NFL schedule and just revealed three teams projected to outright win over 60% of the time, potentially giving you a huge payday. You can only get every pick for every game at SportsLine, and for a limited time, get your first month at SportsLine for just $1 using promo code CHAMPIONSHIP.
So what Wild Card NFL picks can you make with confidence, and which three picks should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Wild Card Weekend NFL betting odds, lines, live spreads, scores
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