The defending AFC South champion Houston Texans are off to a dismal 0-3 start, but look to turn their fortunes around when they take on the Tennessee Titans. Houston has won the AFC South the past two seasons and six out of the past 10 years. Third-year quarterback C.J. Stroud is a big part of Houston’s success. He has thrown for 3,700 yards and 20 touchdowns or more in each of his first two seasons. The latest Week 4 NFL odds list the Texans at -7, with an over/under at 38.5 in what’s one of just three divisional matchups this week. Houston has won three of the last four meetings with Tennessee.
In a game featuring the smallest NFL line of the week, Caleb Williams and the Chicago Bears (+1.5) look to win their second game in a row when they take on the Las Vegas Raiders. Chicago rolled to a 31-14 win over the Dallas Cowboys in Week 3 as Williams passed for four touchdowns. Other tight NFL lines include Jets vs. Dolphins (-2.5), Ravens vs. Chiefs (+2.5), Commanders vs. Falcons (+1) and Vikings vs. Steelers (+2.5) in Dublin, Ireland. Which team has value to include in Week 4 NFL bets, and which side of the NFL spread should you target?
Before locking in any Week 4 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, the model has scoured the Week 4 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 4 NFL picks at SportsLine.
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Top Week 4 NFL picks
After simulating every game 10,000 times, the model is high on the Houston Texans (-7, 38.5) to cover against the Tennessee Titans. The Texans are hoping to build on last year’s team that reached the divisional round of the 2024 playoffs, where they dropped a 23-14 decision to the Kansas City Chiefs. Besides Stroud, Houston’s offense is led by running back Nick Chubb, who has carried 34 times for 141 yards (4.1 average) and one touchdown. He has had one explosive play of 25 yards and has converted seven first downs.
In the passing game, wide receiver Nico Collins leads the Texans with 14 receptions for 181 yards (12.9 average) and two touchdowns. He has had two explosive plays of 20 yards or more, including a long of 50, with 50 yards after the catch and five first-down conversions. In last week’s loss at Jacksonville, he caught eight passes for 104 yards and a score. The model has Houston winning by double digits and covering in well over 50% of simulations. See which other NFL parlay picks to make here, and bet the Texans to cover here:
How to make Week 4 NFL parlays
The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will not only cover, but win outright. You can only see the model’s Week 4 NFL best bets and NFL parlay at SportsLine.
What are the model’s top Week 4 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 4 NFL best bets from a model on an 39-19 run on top-rated picks, and find out.
