{"id":43785,"date":"2026-02-05T05:58:02","date_gmt":"2026-02-05T05:58:02","guid":{"rendered":"https:\/\/naijaglobalnews.org\/?p=43785"},"modified":"2026-02-05T05:58:02","modified_gmt":"2026-02-05T05:58:02","slug":"integrated-structural-dynamics-uncover-a-new-b12-photoreceptor-activation-mode","status":"publish","type":"post","link":"https:\/\/naijaglobalnews.org\/?p=43785","title":{"rendered":"Integrated structural dynamics uncover a new B12 photoreceptor activation mode"},"content":{"rendered":"<p>\n<\/p>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"1.\">\n<p class=\"c-article-references__text\" id=\"ref-CR1\">Kottke, T., Xie, A., Larsen, D. S. &amp; Hoff, W. D. Photoreceptors take charge: emerging principles for light sensing. Annu. Rev. Biophys. 47, 291\u2013313 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"2.\">\n<p class=\"c-article-references__text\" id=\"ref-CR2\">Padmanabhan, S., P\u00e9rez-Casta\u00f1o, R., Osete-Alcaraz, L., Polanco, M. C. &amp; El\u00edas-Arnanz, M. Vitamin B12 photoreceptors. Vitam. Horm. 119, 149\u2013184 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"3.\">\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Banerjee, R. &amp; Ragsdale, S. W. The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes. Annu. Rev. Biochem. 72, 209\u2013247 (2003).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"4.\">\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Ortiz-Guerrero, J. M., Polanco, M. C., Murillo, F. J., Padmanabhan, S. &amp; Elias-Arnanz, M. Light-dependent gene regulation by a coenzyme B12-based photoreceptor. Proc. Natl Acad. Sci. USA 108, 7565\u20137570 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"5.\">\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Jost, M. et al. Structural basis for gene regulation by a B12-dependent photoreceptor. Nature 526, 536\u2013541 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"6.\">\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Poddar, H. et al. A guide to time-resolved structural analysis of light-activated proteins. FEBS J. 289, 576\u2013595 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"7.\">\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Miller, R. J. D., Par\u00e9-Labrosse, O., Sarracini, A. &amp; Besaw, J. E. Three-dimensional view of ultrafast dynamics in photoexcited bacteriorhodopsin in the multiphoton regime and biological relevance. Nat. Commun. 11, 1240 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"8.\">\n<p class=\"c-article-references__text\" id=\"ref-CR8\">Allen, L. H. Vitamin b-12. Adv. Nutr. 3, 54\u201355 (2012).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"9.\">\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Cheng, Z., Yamamoto, H. &amp; Bauer, C. E. Cobalamin\u2019s (Vitamin B12) surprising function as a photoreceptor. Trends Biochem. Sci. 41, 647\u2013650 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"10.\">\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Yu, Y. et al. SignatureFinder enables sequence mining to identify cobalamin-dependent photoreceptor proteins. FEBS J. 292, 635\u2013652 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"11.\">\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Zhang, S. et al. Photocobilins integrate B12 and bilin photochemistry for enzyme control. Nat. Commun. 15, 2740 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"12.\">\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Zheng, Y., Chen, F., Frank, S., Quispe Haro, J. J. &amp; Wegner, S. V. Three-color protein photolithography with green, red, and far-red light. Small 20, 2405687 (2024).<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"13.\">\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Fok, H. K. F. et al. Red-shifting B12-dependent photoreceptor protein via optical coupling for inducible living materials. Angew. Chem. Int. Ed. 63, e202411105 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"14.\">\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Kainrath, S., Stadler, M., Reichhart, E., Distel, M. &amp; Janovjak, H. Green-light-induced inactivation of receptor signaling using cobalamin-binding domains. Angew. Chem. Int. Ed. Engl. 56, 4608\u20134611 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"15.\">\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Chatelle, C. et al. A green-light-responsive system for the control of transgene expression in mammalian and plant cells. ACS Synth. Biol. 7, 1349\u20131358 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"16.\">\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Mansouri, M. et al. Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes. Nat. Commun. 12, 3388 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"17.\">\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Wang, R., Yang, Z., Luo, J., Hsing, I. M. &amp; Sun, F. B12-dependent photoresponsive protein hydrogels for controlled stem cell\/protein release. Proc. Natl Acad. Sci. USA 114, 5912\u20135917 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"18.\">\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Narayan, O. P., Mu, X., Hasturk, O. &amp; Kaplan, D. L. Dynamically tunable light responsive silk-elastin-like proteins. Acta Biomater. 121, 214\u2013223 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"19.\">\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Xu, D., Ricken, J. &amp; Wegner, S. V. Turning cell adhesions ON or OFF with high spatiotemporal precision using the green light responsive protein CarH. Chemistry 26, 9859\u20139863 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"20.\">\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Jost, M., Simpson, J. H. &amp; Drennan, C. L. The transcription factor CarH safeguards use of adenosylcobalamin as a light sensor by altering the photolysis products. Biochemistry 54, 3231\u20133234 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"21.\">\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Bridwell-Rabb, J. &amp; Drennan, C. L. Vitamin B12 in the spotlight again. Curr. Opin. Chem. Biol. 37, 63\u201370 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"22.\">\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Poddar, H. et al. Redox driven B12-ligand switch drives CarH photoresponse. Nat. Commun. 14, 5082 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"23.\">\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Kutta, R. J. et al. The photochemical mechanism of a B12-dependent photoreceptor protein. Nat. Commun. 6, 7907 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"24.\">\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Miller, N. A. et al. The photoactive excited state of the B12-based photoreceptor CarH. J. Phys. Chem. B 124, 10732\u201310738 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"25.\">\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Branden, G. &amp; Neutze, R. Advances and challenges in time-resolved macromolecular crystallography. Science 373, eaba0954 (2021).<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"26.\">\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Weik, M. &amp; Domratcheva, T. Insight into the structural dynamics of light sensitive proteins from time-resolved crystallography and quantum chemical calculations. Curr. Opin. Struct. Biol. 77, 102496 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"27.\">\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Yabashi, M., Tanaka, H. &amp; Ishikawa, T. Overview of the SACLA facility. J. Synchrotron Radiat. 22, 477\u2013484 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"28.\">\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Milne, J. C. et al. SwissFEL: the Swiss X-ray free electron laser. Appl. Sci. 7, 720\u2013777 (2017).<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"29.\">\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Barends, T. R. M. et al. Influence of pump laser fluence on ultrafast myoglobin structural dynamics. Nature 626, 905\u2013911 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"30.\">\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Pounot, K., Schiro, G. &amp; Levantino, M. Tracking the structural dynamics of proteins with time-resolved X-ray solution scattering. Curr. Opin. Struct. Biol. 82, 102661 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"31.\">\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Toda, M. J., Lodowski, P., Mamun, A. A. &amp; Kozlowski, P. M. Photoproduct formation in coenzyme B12-dependent CarH via a singlet pathway. J. Photochem. Photobiol. B 232, 112471 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"32.\">\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Weik, M. &amp; Colletier, J.-P. Temperature-dependent macromolecular X-ray crystallography. Acta Crystallogr. D 66, 437\u2013446 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"33.\">\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Caramello, N. &amp; Royant, A. From femtoseconds to minutes: time-resolved macromolecular crystallography at XFELs and synchrotrons. Acta Crystallogr. D 80, 60\u201379 (2024).<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"34.\">\n<p class=\"c-article-references__text\" id=\"ref-CR34\">von Stetten, D. et al. In crystallo optical spectroscopy (icOS) as a complementary tool on the macromolecular crystallography beamlines of the ESRF. Acta Crystallogr. D 71, 15\u201326 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"35.\">\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Henry, E. R. &amp; Hofrichter, J. in Methods in Enzymology (eds Brand, L. &amp; Johnson, M. L.) Vol. 210, 129\u2013192 (Academic Press, 1992).<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"36.\">\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Toda, M. J., Mamun, A. A., Lodowski, P. &amp; Kozlowski, P. M. Why is CarH photolytically active in comparison to other B12-dependent enzymes? J. Photochem. Photobiol. B 209, 111919 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"37.\">\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Kuta, J., Wuerges, J., Randaccio, L. &amp; Kozlowski, P. M. Axial bonding in alkylcobalamins: DFT analysis of the inverse versus normal trans influence. J. Phys. Chem. A 113, 11604\u201311612 (2009).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"38.\">\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Poddar, H. et al. An unusual light-sensing function for coenzyme B12 in bacterial transcription regulator CarH. Methods Enzymol. 668, 349\u2013372 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"39.\">\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Shoeman, R. L., Hartmann, E. &amp; Schlichting, I. Growing and making nano- and microcrystals. Nat. Protoc. 18, 854\u2013882 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"40.\">\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Stoll, S. &amp; Schweiger, A. EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. J. Magn. Reson. 178, 42\u201355 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"41.\">\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Tono, K. et al. Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser. J. Synchrotron Radiat. 22, 532\u2013537 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"42.\">\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Botha, S. et al. Room-temperature serial crystallography at synchrotron X-ray sources using slowly flowing free-standing high-viscosity microstreams. Acta Crystallogr. D 71, 387\u2013397 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"43.\">\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Shimazu, Y. et al. High-viscosity sample-injection device for serial femtosecond crystallography at atmospheric pressure. J. Appl. Crystallogr. 52, 1280\u20131288 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"44.\">\n<p class=\"c-article-references__text\" id=\"ref-CR44\">Carrillo, M. et al. Micro-structured polymer fixed targets for serial crystallography at synchrotrons and XFELs. IUCrJ 10, 678\u2013693 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"45.\">\n<p class=\"c-article-references__text\" id=\"ref-CR45\">White, T. Processing serial crystallography data with CrystFEL: a step-by-step guide. Acta Crystallogr. D 75, 219\u2013233 (2019).<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"46.\">\n<p class=\"c-article-references__text\" id=\"ref-CR46\">McCoy, A. J. et al. Phaser crystallographic software. J. Appl. Crystallogr. 40, 658\u2013674 (2007).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"47.\">\n<p class=\"c-article-references__text\" id=\"ref-CR47\">Murshudov, G. N. et al. REFMAC5 for the refinement of macromolecular crystal structures. Acta Crystallogr. D\u00a067, 355\u2013367 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"48.\">\n<p class=\"c-article-references__text\" id=\"ref-CR48\">Agirre, J. et al. The CCP4 suite: integrative software for macromolecular crystallography. Acta Crystallogr. D\u00a079, 449\u2013461 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\">ADS\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"49.\">\n<p class=\"c-article-references__text\" id=\"ref-CR49\">Emsley, P., Lohkamp, B., Scott, W. G. &amp; Cowtan, K. Features and development of Coot. Acta Crystallogr. D\u00a066, 486\u2013501 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\">ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"50.\">\n<p class=\"c-article-references__text\" id=\"ref-CR50\">Ursby, T. &amp; Bourgeois, D. Improved estimation of structure-factor difference amplitudesfrom poorly accurate data. Acta Crystallogr. A 53, 564\u2013575 (1997).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"51.\">\n<p class=\"c-article-references__text\" id=\"ref-CR51\">Genick, U. Structure-factor extrapolation using the scalar approximation: theory, applications and limitations. Acta Crystallogr. D 63, 1029\u20131041 (2007).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"52.\">\n<p class=\"c-article-references__text\" id=\"ref-CR52\">De Zitter, E., Coquelle, N., Oeser, P., Barends, T. R. M. &amp; Colletier, J. P. Xtrapol8 enables automatic elucidation of low-occupancy intermediate-states in crystallographic studies. Commun. Biol. 5, 640 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"53.\">\n<p class=\"c-article-references__text\" id=\"ref-CR53\">Liebschner, D. et al. Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix. Acta Crystallogr. D\u00a075, 861\u2013877 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"54.\">\n<p class=\"c-article-references__text\" id=\"ref-CR54\">Gorel, A., Schlichting, I. &amp; Barends, T. R. M. Discerning best practices in XFEL-based biological crystallography \u2014 standards for nonstandard experiments. IUCrJ 8, 532\u2013543 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"55.\">\n<p class=\"c-article-references__text\" id=\"ref-CR55\">Horrell, S. et al. Fixed target serial data collection at diamond light source. J. Vis. Exp. 168, e62200 (2021).<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"56.\">\n<p class=\"c-article-references__text\" id=\"ref-CR56\">McCarthy, A. A. et al. Current and future perspectives for structural biology at the Grenoble EPN campus: a comprehensive overview. J. Synchrotron Radiat. 32, 577\u2013594 (2025).<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"57.\">\n<p class=\"c-article-references__text\" id=\"ref-CR57\">Wulff, M. et al. The realization of sub-nanosecond pump and probe experiments at the ESRF. Faraday Discuss. 122, 13\u201326 (2003).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"58.\">\n<p class=\"c-article-references__text\" id=\"ref-CR58\">Cammarata, M. et al. Chopper system for time resolved experiments with synchrotron radiation. Rev. Sci. Instrum. 80, 015101 (2009).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"59.\">\n<p class=\"c-article-references__text\" id=\"ref-CR59\">Gaussian 16 Rev. A.03 (Wallingford, CT, 2016).<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"60.\">\n<p class=\"c-article-references__text\" id=\"ref-CR60\">Becke, A. D. Density-functional thermochemistry. III. The role of exact exchange. J. Chem. Phys. 98, 5648\u20135652 (1993).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"61.\">\n<p class=\"c-article-references__text\" id=\"ref-CR61\">Kornobis, K. et al. Electronically excited states of vitamin B12: benchmark calculations including time-dependent density functional theory and correlated ab initio methods. J. Phys. Chem. A 115, 1280\u20131292 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"62.\">\n<p class=\"c-article-references__text\" id=\"ref-CR62\">Hirao, H. Which DFT functional performs well in the calculation of methylcobalamin? Comparison of the B3LYP and BP86 functionals and evaluation of the impact of empirical dispersion correction. J. Phys. Chem A 115, 9308\u20139313 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"63.\">\n<p class=\"c-article-references__text\" id=\"ref-CR63\">Grimme, S., Ehrlich, S. &amp; Goerigk, L. Effect of the damping function in dispersion corrected density functional theory. J. Comput. Chem. 32, 1456\u20131465 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"64.\">\n<p class=\"c-article-references__text\" id=\"ref-CR64\">Grimme, S., Antony, J., Ehrlich, S. &amp; Krieg, H. A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. J. Chem. Phys. 132, 154104 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    PubMed\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"65.\">\n<p class=\"c-article-references__text\" id=\"ref-CR65\">Maier, J. A. et al. ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB. J. Chem. Theory Comput. 11, 3696\u20133713 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"66.\">\n<p class=\"c-article-references__text\" id=\"ref-CR66\">Case, D. A. et al. AmberTools. J. Chem. Inf. Model. 63, 6183\u20136191 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<br \/>\n    PubMed\u00a0<br \/>\n    PubMed Central\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"67.\">\n<p class=\"c-article-references__text\" id=\"ref-CR67\">Marques, H. M., Ngoma, B., Egan, T. J. &amp; Brown, K. L. Parameters for the amber force field for the molecular mechanics modeling of the cobalt corrinoids. J. Mol. Struct. 561, 71\u201391 (2001).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"68.\">\n<p class=\"c-article-references__text\" id=\"ref-CR68\">Perdew, J. P. Density-functional approximation for the correlation energy of the inhomogeneous electron gas. Phys. Rev. B 33, 8822\u20138824 (1986).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"69.\">\n<p class=\"c-article-references__text\" id=\"ref-CR69\">Runge, E. &amp; Gross, E. K. U. Density-functional theory for time-dependent systems. Phys. Rev. Lett. 52, 997\u20131000 (1984).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"70.\">\n<p class=\"c-article-references__text\" id=\"ref-CR70\">Becke, A. D. Density-functional exchange-energy approximation with correct asymptotic behavior. Phys. Rev. A 38, 3098\u20133100 (1988).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"71.\">\n<p class=\"c-article-references__text\" id=\"ref-CR71\">Weigend, F., H\u00e4ser, M., Patzelt, H. &amp; Ahlrichs, R. RI-MP2: optimized auxiliary basis sets and demonstration of efficiency. Chem. Phys. Lett. 294, 143\u2013152 (1998).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    ADS\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"72.\">\n<p class=\"c-article-references__text\" id=\"ref-CR72\">Eichkorn, K., Weigend, F., Treutler, O. &amp; Ahlrichs, R. Auxiliary basis sets for main row atoms and transition metals and their use to approximate Coulomb potentials. Theor. Chem. Acc. 97, 119\u2013124 (1997).<\/p>\n<p class=\"c-article-references__links u-hide-print\">Article\u00a0<br \/>\n    CAS\u00a0<\/p>\n<p>                    Google Scholar\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"73.\">\n<p class=\"c-article-references__text\" id=\"ref-CR73\">Frisch, M. J. et al. Gaussian 09, revision B.01. (2010).<\/p>\n<\/li>\n","protected":false},"excerpt":{"rendered":"<p>Kottke, T., Xie, A., Larsen, D. S. &amp; Hoff, W. D. Photoreceptors take charge: emerging principles for light sensing. Annu. Rev. Biophys. 47, 291\u2013313 (2018). Article\u00a0 CAS\u00a0 PubMed\u00a0 Google Scholar\u00a0 Padmanabhan, S., P\u00e9rez-Casta\u00f1o, R., Osete-Alcaraz, L., Polanco, M. C. &amp; El\u00edas-Arnanz, M. Vitamin B12 photoreceptors. Vitam. Horm. 119, 149\u2013184 (2022). Article\u00a0 CAS\u00a0 PubMed\u00a0 Google Scholar\u00a0<\/p>\n","protected":false},"author":1,"featured_media":43786,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58],"tags":[22844,22842,22841,7039,2067,22843,7862,776],"class_list":{"0":"post-43785","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-science","8":"tag-activation","9":"tag-b12","10":"tag-dynamics","11":"tag-integrated","12":"tag-mode","13":"tag-photoreceptor","14":"tag-structural","15":"tag-uncover"},"_links":{"self":[{"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/posts\/43785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43785"}],"version-history":[{"count":0,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/posts\/43785\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/media\/43786"}],"wp:attachment":[{"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}