\n<\/p>\n
A three-minute brainwave test can detect memory problems linked to Alzheimer\u2019s disease long before people are typically diagnosed, raising hopes that the approach could help identify those most likely to benefit from new drugs for the condition.<\/p>\n
In a small trial, the test flagged specific memory issues in people with mild cognitive impairment, highlighting who was at greater risk of developing Alzheimer\u2019s. Trials in larger groups are under way.<\/p>\n
The Fastball test is a form of electroencephalogram (EEG) that uses small sensors on the scalp to record the brain\u2019s electrical activity while people watch a stream of images on a screen. The test detects memory problems by analysing the brain\u2019s automatic responses to images the person sees before the test.<\/p>\n
\u201cThis shows us that our new passive measure of memory, which we\u2019ve built specifically for Alzheimer\u2019s disease diagnosis, can be sensitive to those individuals at very high risk but who are not yet diagnosed,\u201d said Dr George Stothart, a cognitive neuroscientist at the University of Bath, where the test was developed.<\/p>\n
The trial, run with the University of Bristol, involved 54 healthy adults and 52 patients with mild cognitive impairment (MCI). People with MCI have problems with memory, thinking or language, but these are not usually severe enough to prevent them doing their daily activities.<\/p>\n
Before the test, volunteers were shown eight images and told to name them, but not specifically to remember them or look out for them in the test. The researchers then recorded the participants\u2019 brain activity as they watched hundreds of images flash up on a screen. Each image appeared for a third of a second and every fifth picture was one of the eight they had seen before.<\/p>\n
<\/span>Dr George Stothart from the University of Bath with John Stennard, one of the 54 healthy adults involved in the trial.<\/span> Photograph: BRACE Dementia Research<\/p>\n The scientists found that those with amnestic MCI, which largely affects a person\u2019s memory for objects, had reduced responses to the test compared with healthy adults and those with non-amnestic MCI. People with amnestic MCI are many times more likely to develop Alzheimer\u2019s disease than those with non-amnestic MCI.<\/p>\n The test cannot identify who will definitely develop Alzheimer\u2019s disease. But if larger studies confirm the findings, it could help doctors assess early on which patients are at high risk and could benefit most from new Alzheimer\u2019s drugs such as donanemab and lecanemab.<\/p>\n All of the tests were performed in people\u2019s homes, which Stothart said was important for making them accessible and reducing people\u2019s anxiety. Details are published in Brain Communications.<\/p>\n Prof Vladimir Litvak, of UCL\u2019s Queen Square Institute of Neurology, said it was \u201can early step towards developing a clinically useful test\u201d. A crucial next step, he said, would be to determine whether it can predict how a person\u2019s condition changes over time and inform decisions about their treatment.<\/p>\n Dr Julia Dudley, of Alzheimer\u2019s Research UK, said: \u201cIt\u2019s encouraging to see studies exploring potential ways to detect memory problems earlier. New Alzheimer\u2019s treatments are proving to be more effective when given at earlier stages in the disease, therefore earlier diagnosis is key for people to benefit from this.<\/p>\n \u201cLonger-term studies in larger, diverse groups of people are needed to find out if this technology can predict how memory problems will unfold over time. Memory impairment can also be linked to other health conditions, not just dementia. Future research should look at how other factors may influence brainwave test results and explore how these tests could work alongside other diagnosis tools like cognitive assessments and blood tests.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":" A three-minute brainwave test can detect memory problems linked to Alzheimer\u2019s disease long before people are typically diagnosed, raising hopes that the approach could help identify those most likely to benefit from new drugs for the condition. In a small trial, the test flagged specific memory issues in people with mild cognitive impairment, highlighting who<\/p>\n","protected":false},"author":1,"featured_media":18609,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[55],"tags":[10032,189,2169,7643,7710,3140,364,3141,736,76,11374,2131],"class_list":{"0":"post-18608","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-social-issues","8":"tag-alzheimers","9":"tag-finds","10":"tag-greater","11":"tag-helps","12":"tag-identify","13":"tag-medical","14":"tag-people","15":"tag-research","16":"tag-risk","17":"tag-test","18":"tag-threeminute","19":"tag-trial"},"_links":{"self":[{"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/posts\/18608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18608"}],"version-history":[{"count":0,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/posts\/18608\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=\/wp\/v2\/media\/18609"}],"wp:attachment":[{"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/naijaglobalnews.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}